Biohybrid hand uses sushi-like rolls of lab-grown human muscle to move objects

A biohybrid hand which can move objects and do a scissor gesture has been built by a team at the University of Tokyo and Waseda University in Japan. The researchers used thin strings of lab-grown muscle tissue bundled into sushi-like rolls to give the fingers enough strength to contract.

These multiple muscle tissue actuators (MuMuTAs), created by the researchers, are a major development towards building larger biohybrid limbs. While currently limited to the lab environment, MuMuTAs have the potential to advance future biohybrid prosthetics, aid drug testing on muscle tissue and broaden the potential of biohybrid robotics to mimic real-life forms.

“Rock, paper, scissors” is a classic schoolyard game or quick-fire way to make decisions for the indecisive. But choose paper and you are going to lose to this robot hand, which has mastered the art of the scissor gesture. And while it might seem like a simple motion, in the realm of biohybrids and prosthetic limbs, this is a leap forward towards new levels of realism and usability.

The hand is made of a 3D-printed plastic base, with tendons of human muscle tissue which move the fingers. Until now, biohybrid devices have typically been on a much smaller scale (about 1-centimeter long) or limited to simpler or single-joint movements. By contrast, the biohybrid hand is 18 cm in length and has multijointed fingers, which can be moved individually to make gestures or in combination to manipulate objects.

“Our key achievement was developing the MuMuTAs. These are thin strands of muscle tissue grown in a culture medium and then rolled up into a bundle like a sushi roll to make each tendon,” explained Professor Shoji Takeuchi from the University of Tokyo.

“Creating the MuMuTAs enabled us to overcome our biggest challenge, which was to ensure enough contractile force and length in the muscles to drive the hand’s large structure.”

Thick muscle tissue which is needed to move larger limbs is difficult to grow in the lab, as it suffers from necrosis. This is when insufficient nutrients reach the center of the muscle, resulting in tissue loss. However, by using multiple thin muscle tissues bundled together to act as one larger muscle, the team was able to create tendons with enough strength.

The MuMuTAs are stimulated using electrical currents, delivered through waterproof cables.

To test the abilities of the hand, the team manipulated the fingers to form a scissor gesture by contracting the little finger, ring finger and thumb. They also used the fingers to grasp and move the tip of a pipette. This demonstrated the hand’s ability to mimic a range of actions, as the multijointed fingers can be flexed either separately or at the same time, an impressive feat.

Using real muscle tissue does, however, come with some downsides, as anyone who has been to the gym may know.

“While not entirely surprising, it was interesting that the contractile force of the tissues decreased and showed signs of fatigue after 10 minutes of electrical stimulation, yet recovered within just one hour of rest. Observing such a recovery response, similar to that of living tissues, in engineered muscle tissues was a remarkable and fascinating outcome,” said Takeuchi.

Currently, the hand must be suspended in liquid so that the “anchors,” or ties, which connect the muscles to the hand can float without friction, allowing the fingers to move smoothly. However, the team believes that with further development, it will be possible to build a free-moving hand.

Another further challenge with the current design is that the fingers cannot be intentionally returned to their straight starting position but do so by floating into place. Adding an elastic material to snap them back into position, or more MuMuTAs on the back of the fingers which contract in the opposite direction, would enable more control over finger movement.

“A major goal of biohybrid robotics is to mimic biological systems, which necessitates scaling up their size. Our development of the MuMuTAs is an important milestone for achieving this,” said Takeuchi.

“The field of biohybrid robotics is still in its infancy, with many foundational challenges to overcome. Once these basic hurdles are addressed, this technology could be used in advanced prosthetics, and could also serve as a tool for understanding how muscle tissues function in biological systems, to test surgical procedures or drugs targeting muscle tissues.”